Structure

 

 

 

To study the effect of electrical pulses on the plasma membrane permeability of cells (bacteria, yeast, algae as well as mammalian): a) to study the effect of plasma membrane permeability on the viability of wall-containing microorganisms; (b) to study the link between plasma membrane and cell-wall permeabilization and to search for selective test methods for this purpose; c) to investigate the mechanism of recovery of the permeabilized wall; (d) to develop and implement of electroporation-based technologies for the control of harmful micro-organisms;

 

To study the effect of short (nanosecond) electrical pulses on intracellular signals: a) to study the effect of plasma membrane permeability on the programmable death (apoptosis) of wall-containing microorganisms; (b) to investigate the mechanism of apoptosis of microorganisms induced by electrical and magnetic pulses; (c) to engineer gene expression promotors for controlled induction by electrical pulses;

 

To investigate the effect of abiotic factors such as light, temperature and electric field on cellular signals: a) to investigate the effects of nanostructured surfaces on thermal- and opto-permeabilization of cells; (b) to investigate cryoprotection mechanisms for cells and tissue; (c) to develop and apply new optically transparent polymeric materials for photodynamic therapy; d) to develop organ-on-a-chip devices to investigate electrically induced intercellular signals.